Complement activation in progressive renal disease

Complement activation profiles in disease.

Complement is an acute-reacting non-specific effector system. Activation and consumption of individual components of this multicomponent system occur secondarily to specific complement fixing events. The complement system is therefore an indirect and imprecise diagnostic tool and can be used clinically only as a general indicator of the severity of a particular disease or as a monitor of its pr...

A Protein's Role in Progressive Renal Disease

Cardiovascular risk factors in progressive renal disease.

the leading causes of mortality and morbidity in the western world. Epidemiological studies have identified important physiological and lifestyle risk factors for CVD (Table 1)1. More encouragingly, evidence from a number of randomised controlled trials and meta-analyses has now demonstrated that this disease may largely be prevented (at least in the general population) by lifestyle modificatio...

Activation of complement in relation to disease.

Chronic progression of tubulointerstitial damage in proteinuric renal disease is mediated by complement activation: a therapeutic role for complement inhibitors?

The mechanisms by which increased urinary protein concentrations lead to nephrotoxic injury are certain to be multifactorial and involve complex interactions between numerous pathways of cellular damage mediated by both cellular and humoral pathways. These may include a major role for the podocyte in glomerular diseases leading to chronic renal failure, the loss of microvascular endothelium, th...